ABSTRACT
Background: It has been reported that dyslipidemia is related to coronavirus-related diseases. Critical patients with coronavirus disease 2019 (COVID-19) who suffered from multiple organ dysfunctions were treated in the intensive care unit (ICU) in Wuhan, China. Whether the lipids profile was associated with the prognosis of COVID-19 in critical patients remained unclear. Methods: A retrospective study was performed in critical patients (N=48) with coronavirus disease 2019 in Leishenshan hospital between February and April 2020 in Wuhan. The parameters including lipid profiles, liver function, and renal function were collected on admission day, 2-3days after the admission, and the day before the achievement of clinical outcome. Results: Albumin value and creatine kinase (ck) value were statistically decreased at 2-3 days after admission compared with those on admission day (P<0.05). Low density lipoprotein (LDL-c), high density lipoprotein (HDL-c), apolipoprotein A (ApoA), and apolipoprotein A (Apo B) levels were statistically decreased after admission (P<0.05). Logistic regression showed that HDL-c level both on admission day and the day before the achievement of clinical outcome were negatively associated with mortality in critical patients with COVID-19. Total cholesterol (TC) level at 2-3days after admission was related to mortality in critical patients with COVID-19. Conclusions: There were lipid metabolic disorders in the critical patients with COVID-19. Lower levels of HDL-c and TC were related to the progression of critical COVID-19.
Subject(s)
COVID-19/mortality , Dyslipidemias/epidemiology , Hospital Mortality , Multiple Organ Failure/mortality , Aged , Aged, 80 and over , Apolipoproteins A/blood , Apolipoproteins B/blood , COVID-19/blood , COVID-19/epidemiology , China/epidemiology , Cholesterol/blood , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Critical Illness , Dyslipidemias/blood , Female , Humans , Male , Middle Aged , Multiple Organ Failure/blood , Multiple Organ Failure/epidemiology , Retrospective Studies , Risk Factors , SARS-CoV-2 , Severity of Illness IndexABSTRACT
The outbreak of coronavirus disease 2019 (COVID-19) and its global epidemic shocked the world, which inspired the new thinking of food structure and consumption pattern from consumers. The scientific concept of nutrition and health and the appeals of good life caused wide society attention. It is bound to profoundly influence food industry, especially to the emerging industry of food for special medical purposes (FSMP). Face to the epidemic outbreak of COVID-19 without specific drugs, nutritional support treatment is an important intervention method for front-line treatment, and there is no FSMP for patients with COVID-19 yet. Based on the characteristics and nutritional needs of patients with respiratory system disease, the development concept of product suitable for diagnosis and treatment of respiratory diseases was designed via the adjustment of energy supply of macronutrients and the addition of microelement. The specific full-nutritional powder, emulsion, and functional fat emulsion for respiratory system diseases were designed via research and optimization of raw material screening and process, which should be applied strongly for nutritional treatment and life support after the epidemic.